1. Mode of binding, kinetic and thermodynamic properties of a lipid-like drug (Fingolimod) interacting with Human Serum Albumin

Samira Gholizadeh , Hossein Haghaei, Hosna Karami, Somaieh Soltani* , Mostafa Zakariazadeh, Javad Shokri

Bioimpacts. 2023;13(2): 109-121. doi: 10.34172/bi.2022.23383

PMCID: PMC10182447 PMID: 37193080 Scopus ID: 85152094869

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Interaction of the Fingolimod with HSA was studied using multi-spectroscopic and molecular modeling methods. Fingolimod binds to the binding site II of HSA via hydrogen bonds and Van der Walls forces. The binding is enthalpy driven. Fingolimod interaction with HSA leads to the conformational change of HSA.

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